{"id":10719,"date":"2016-01-04T10:41:47","date_gmt":"2016-01-04T09:41:47","guid":{"rendered":"http:\/\/www.departamentomedicinaclinicaumh.es\/?p=10719"},"modified":"2024-02-23T10:38:51","modified_gmt":"2024-02-23T10:38:51","slug":"eliseo-pascual-nature-sobre-la-naturaleza-cronica-y-progresiva-de-la-gota-en-ausencia-de-tratamiento","status":"publish","type":"post","link":"https:\/\/departamentomedicinaclinica.umh.es\/en\/2016\/01\/04\/eliseo-pascual-nature-sobre-la-naturaleza-cronica-y-progresiva-de-la-gota-en-ausencia-de-tratamiento\/","title":{"rendered":"Eliseo Pascual in Nature on the nature of chronic and progressive of gout in the absence of treatment"},"content":{"rendered":"

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Eliseo Pascual G\u00f3mez<\/strong><\/a>, emeritus professor of Medicine the UMH and ex-chief of Rheumatology of the General University Hospital of Alicante (Spain) has recently published a research article in the prestigious journal Nature Reviews in Rheumatology<\/a>.<\/em>\u00a0On the nature of chronic and progressive of gout \u00a0in the absence of treatment, under the title: \u201cMechanisms of formation of crystals in the gout. A structural approach\u201d<\/a>, professor Pascual<\/strong> get relevant data and unknown to allow\u00a0understanding gout<\/strong>\u00a0\u00a0in breadth as crystal deposit disease. The work lays the basis for understanding how and place are constituted of monosodium urate crystals in the gout. These principles enable a greater understanding of the evolutionary and chronic nature of the disease of gout in the absence of treatment or if it is inefficient.<\/p>\n

\"Gout

Articular cartilage surface on collagen fibers of cartilage in a process of very early osteoarthritis. Here the crystals form very orderly rows along ripples in bands of collagen<\/p><\/div>
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“Nature of chronic and progressive of gout in the absence of treatment” how is gout formed?<\/h2>\n

The gout disease<\/strong> appears as acute and painful phases of Arthritis<\/strong>, primarily of various joints of the foot, but also of other joints. Gout is basically due to the formation and deposit of a salt crystals (monosodium urate) uric acid from the body itself, mainly in joints. They are essential high levels of uric acid in blood to the formation of crystals, however, were unknown mechanisms that made possible the formation of these particles and the place of origin of its emergence. That lack of information was that the crystals are dissolved during the process of fixation of tissue, essential to their staining and review by pathologists. Therefore, they do not appear in histological preparations.
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What is it in study NATURE OF CHRONIC AND PROGRESSIVE OF GOUT IN ABSENCE OF TREATMENT BY PROFESSOR Eliseo Pascual G\u00f3mez?<\/h2>\n

The possibility of the realization of the study of the professor and researcher of the University Miguel Hern\u00e1ndez of Elche (Spain)<\/a>, Eliseo Pascual G\u00f3mez<\/a>, was made possible by the appreciation of collagen fibers on the surface of cartilage with a tidy crystals deposit. Subsequently, in carrying out histological preparations through surgical biopsies (cuts after freezing of the tissue without setting), where you can see the conservation of crystals, as well as the reasonable deduction of training mechanisms. All this, coupled with recent data on the specific location of the urate crystals, obtained by ultrasound of high precision, resulting in a full image in the process of formation of these crystals so far unknown.
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\u00bfHow are crystals formed in the disease of gout?<\/h2>\n

Mainly, crystals are the surface of cartilage joint on cartilage Collagen fibers, which have previously been altered by a process of very early osteoarthritis. In this case, the crystals form orderly rows along ripples that present these bands to be freed and retract. In addition, van forming inside of various tendons, such as:<\/p>\n